CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 75 enrolled
Drug / intervention
Hypochlorous Acid +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03174756
NCT03174756Phase 2Completed
CompareCT.gov

EVALUATION OF THE HYPOCHLOROUS ACID SUBSTANTIVITY AS ANTI-PLAQUE AGENT. A RANDOMIZED CONTROLLED TRIAL

Universidad El Bosque, Bogotá·interventional·Posted Jun 2, 2017·Updated Oct 26, 2017

In Brief

A Phase 2 clinical trial evaluating Hypochlorous Acid, Chlorhexidine, and 1 other intervention for Hypochlorous Acid and Mouthwashes. Completed, enrolled 75 participants across 1 site.

Detailed Summary

Hypochlorous acid (HOCl) in a non-antibiotic antimicrobial agent used in clinical medicine. Nevertheless, its antiplaque oral effect has not been evaluated. Chlorhexidine (CHX) is the gold standard as an antiplaque agent for its high substantivity in plaque and saliva. There are no published studies evaluating the substantivity of hypochlorous acid compared to CHX. Objective: To evaluate the efficacy of mouthwashes of HOCl in substantivity evaluated by reduction of bacterial viability in saliva during 7 hours compared to CHX rinses and a placebo.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypochlorous Acid, Mouthwashes
CountriesColombia
Collaborators--

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedJun 2, 2017
Enrollment StartJan 15, 2015
Primary CompletionNov 15, 2016
Study CompletionNov 30, 2016
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 9.1 years ago

Interventions

Hypochlorous Aciddrug

Mouthwashes of antiplaque agents

Chlorhexidinedrug

A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Placeboother

Sterile water as placebo