At a glance
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Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso
In Brief
A Phase 4 clinical trial evaluating Azithromycin, Amoxicillin, and 2 other interventions for Child Development. Completed, enrolled 252 participants across 2 sites in 2 countries.
Detailed Summary
The use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome. This study is designed to estimate the effect of antibiotic consumption on microbiome in a rural region of rural Burkina Faso. Changes in the intestinal and nasopharyngeal microbiome and resistome following a short course of antibiotics will be measured.
Study Details
Timeline
Interventions
Children in this arm will receive Azithromycin once a day.
Children in this arm will receive Amoxicillin twice a day.
Children in this arm will receive co-trimoxazole once a day.
Children in this arm will receive Placebo once a day.