At a glance
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Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery
In Brief
A Phase 4 clinical trial evaluating Methylprednisolone for Post-operative Edema and Steroid Use. Completed, enrolled 180 participants across 1 site.
Detailed Summary
The current standard of care at the Oral and Maxillofacial Department at the CDHA is the use of one gram of methylprednisolone administered intravenously prior to orthognathic surgery. This is largely based on the work of Habal. The administration of one gram of methylprednisolone can be concerning for the anesthesiologist since this is an unusually large dose of steroid in comparison to use in other surgical specialties. As with most medications, the chances of steroid-related complications increase with increasing doses of steroids. The researchers are proposing a prospective, double-blind randomized control trial to determine if a smaller dose of methylprednisolone (125mg) can be used safely and effectively instead of one gram of methylprednisolone.
Study Details
Timeline
Interventions
Administration of 1000mg vs 125mg methylprednisolone preoperatively in orthognathic surgery.