CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 150 enrolled
Drug / intervention
HOME +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03190889
NCT03190889N/ACompleted

Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes

Mayo Clinic·interventional·Posted Jun 19, 2017·Updated Mar 11, 2026

In Brief

A clinical study evaluating HOME and TNMT for Rehabilitation and ACL Reconstruction. Completed, enrolled 150 participants across 4 sites.

Detailed Summary

The overall goal of this project is to reduce risk of second anterior cruciate ligament (ACL) injury in vulnerable populations (active athletes between 14 = 24 years old) through the identification of relative injury risk groups based on subject-specific movement patterns prior to second injury, as well as through the determination of effect for differential rehabilitation protocols following initial ACL reconstruction and prior to return to sport. As nearly one-third of athletes who have a primary ACL injury and return to sport will experience a secondary injury, results from the proposed work will allow us to prospectively identify high risk patients who are the most appropriate recipients of enhanced treatment, including targeted training, which may reduce the risk of second ACL injury. Secondary ACL injury has the potential to end athletic careers, promote the development of osteoarthritis, and have debilitating effects on quality of life. Hence, the information gathered in this investigation will offer ACL injured athletes the optimal potential to reduce or potentially prevent these negative health effects before they are initiated.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedJun 19, 2017
Enrollment StartAug 1, 2018
Primary CompletionJun 30, 2024
TodayJul 2, 2026
Enrollment to primary: 5.9 yearsPosted 9.0 years ago

Interventions

HOMEother

At home rehabilitation following ACL reconstructive surgery as described in the HOME arm.

TNMTother

Standard of care, clinical rehabilitation following ACL reconstructive surgery with the addition of specified targeted neuromuscular training as described in the TNMT arm.