CI

At a glance

ClinicalIndex Comparison Record
N/ARecruiting· 30 target
Drug / intervention
Neuromuscular Electrical Stimulation (NMES) +1 moredevice
Likely dose
Not stated in record
Key inclusion· 6
  • ✓Aneurysmal SAH diagnosis
  • ✓Aneurysm repaired within 48 hours of symptom onset
  • ✓Age 25-80 years
  • ✓Expected ICU stay >72 hours
Key exclusion· 15
  • ✕SAH from trauma or secondary causes
  • ✕Unlikely to survive one week post-hemorrhage
  • ✕Unlikely to remain in ICU >7 days
  • ✕BMI <15 or >40 kg/m²

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

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NCT03201094N/ARecruitingMonitorCompletion was 1mo ago
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Impact of Neuromuscular Stimulation and High Protein Nutritional Supplementation on Long-term Recovery After Aneurysmal Subarachnoid Hemorrhage.

University of Maryland, Baltimore·interventional·Posted Jun 28, 2017·Updated May 19, 2026

In Brief

A clinical study evaluating Neuromuscular Electrical Stimulation (NMES) and High Protein Supplementation for Subarachnoid Hemorrhage and 3 related conditions. Currently recruiting, targeting 30 participants across 1 site.

Signals

Enrolling slower than its timeline implies

Detailed Summary

The study purpose is to investigate the hypothesis that in adults with SAH, early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will improve muscle mass, metabolic and inflammatory biomarker profiles, compared to SAH controls receiving standard of care interventions for nutrition and mobilization. The investigators will accomplish this by studying the effects of a high protein (HPRO) nutritional treatment as well as NMES intervention have upon muscle wasting and motor strength acutely after SAH. This will be addressed in a prospective trial of SAH patients receiving HRPO with NMES as compared to age and severity-matched SAH patients undergoing standard of care interventions for nutrition and mobilization. Additionally, the study will investigate the impact HPRO and NMES interventions have upon inflammatory cytokines and markers of energy balance. Results of this study will establish evidence for precision nutrition plus early exercise to mitigate the catabolic and inflammatory state produced by SAH to improve muscle, metabolic, and health recovery outcomes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSubarachnoid Hemorrhage, Muscle Atrophy, Inflammation, Nutritional and Metabolic Disease
CountriesUnited States
Collaborators--

Timeline

N/ARecruiting
2018201920202021202220232024202520262027
First PostedJun 28, 2017
Enrollment StartDec 1, 2017
Primary CompletionMay 31, 2026
Study CompletionOct 30, 2026
TodayJul 2, 2026
Enrollment to primary: 8.5 yearsPosted 9.0 years ago

Interventions

Neuromuscular Electrical Stimulation (NMES)device

Neuromuscular electrical stimulation twice daily during study period.

High Protein Supplementationdietary

High protein supplementation with whey protein shakes taken three times a day during study period.