At a glance
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The Use of Microneedles With Topical Botulinum Toxin for Treatment of Palmar Hyperhidrosis
In Brief
A Phase 1 clinical trial evaluating Microneedle, Sham Microneedle, and 2 other interventions for Hyperhidrosis. Completed, enrolled 13 participants across 1 site.
Detailed Summary
Hyperhidrosis or sweating of palms results from the overactivity of sweat glands and leads to psychosocial impairment with reduction in quality of life in those that are affected. Injection of botulinum toxin has been shown to be effective in reducing the symptoms of hyperhidrosis with associated improvement in quality of life, but is usually very painful. Microneedles are a different modality for transdermal drug penetration without the pain. This study aims to understand if botulinum toxin A can be delivered topically after microneedle pretreatment in hopes of developing a minimally painful treatment protocol for treatment of palmar hyperhidrosis.
Study Details
Timeline
Interventions
Microneedles are small needles used to create holes in the stratum corneum (top layer of skin) with relatively low amount of pain.
Flat roller with no needles on the roller
Botulinum toxin type A will be applied to the palm
Saline applied to the palm