At a glance
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Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements?
In Brief
A Phase 4 clinical trial evaluating Vecuronium 0.1 mg/kg and Vecuronium 0.2mg/kg for Arthropathy of Hip. Completed, enrolled 116 participants across 1 site.
Detailed Summary
During many surgeries, increased muscle tension makes it harder for the surgeon to expose the site of surgery and work within the incision. Neuromuscular blockade (NMB) drugs such as Vecuronium bind to neurotransmitter (acetyl choline) receptors at the neuromuscular junction, blocking their action and producing muscle relaxation. This muscle relaxation allows easier retraction of muscle tissues and manipulation of structures in the wound. Improved surgical conditions are likely to result in improved patient outcomes. While increased depths of NMB have been shown to optimize surgical conditions during intra-abdominal and retroperitoneal procedures, the impact of NMB depth has not been reported for orthopedic surgeries.1 To address this, we propose to study the effect of NMB depth on surgical conditions during total hip replacement (THR).
Study Details
Timeline
Interventions
Vecuronium will be administered to achieve and maintain 1 to 2 TOF contractions.
Vecuronium will be administered to achieve and 0 TOF/PTC 1-2.