CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 90 enrolled
Drug / intervention
Analysis of selected single nucleotide polymorphisms (SNPs) +3 moregenetic
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03225950
NCT03225950N/ACompleted
CompareCT.gov

Interaction Between Immune Cells and Bacteria Associated With Periodontitis

University of Copenhagen·observational·Posted Jul 21, 2017·Updated Mar 24, 2020

In Brief

An observational study evaluating In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, and 2 other interventions for Periodontal Diseases and 12 related conditions. Completed, enrolled 90 participants across 2 sites.

Detailed Summary

This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease. Specifically, we collect a spit and blood sample to conduct in vitro stimulations and measurements of selected parameters related to periodontitis to clarify obscure areas in the immunologic pathogenesis of this disease.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsPeriodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease, Microbial Disease, Periodontal Pocket, Inflammation, Inflammation Gum, Dysbiosis, Rheumatoid Arthritis, Generalized Aggressive Periodontitis, Generalized Chronic Periodontitis, Chronic Periodontitis
CountriesDenmark
CollaboratorsCopenhagen University Hospital, Denmark

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedJul 21, 2017
Enrollment StartFeb 1, 2017
Primary CompletionOct 12, 2018
Study CompletionMar 23, 2020
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 8.9 years ago

Interventions

In vitro stimulation of blood with periodontitis-associated- and control bacteriaother

Peripheral mononuclear blood cells are stimulated with periodontitis-associated- and control bacteria to measure the amount of positive cytokine-producing cells.

Anti-CCP- and anti-P.g.-antibodies titersother

Anitbody titers will be measured in saliva and serum samples.

Analysis of selected single nucleotide polymorphisms (SNPs)genetic

DNA obtained from saliva samples will be used to determine the genotype of the participants for selected SNPs.

periodontitis-associated bacteria presenceother

Determination of the presence of periodontitis-associated bacteria e.i. Porphyromonas gingivalis in saliva and blood samples.