CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 84 enrolled
Drug / intervention
Anastrozole +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03229499
NCT03229499Phase 2Completed
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Pulmonary Hypertension and Anastrozole Trial (PHANTOM)

University of Pennsylvania·interventional·Posted Jul 25, 2017·Updated May 1, 2024

In Brief

A Phase 2 clinical trial evaluating Anastrozole and Placebo Oral Tablet for Pulmonary Arterial Hypertension. Completed, enrolled 84 participants across 7 sites.

Detailed Summary

The primary objectives of this study are to determine whether the study drug, anastrozole may improve six minute walk distance at six months compared to placebo and to assess safety and side effects up to twelve months in pulmonary arterial hypertension (PAH).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPulmonary Arterial Hypertension
CountriesUnited States
CollaboratorsNational Heart, Lung, and Blood Institute (NHLBI), Johns Hopkins University, University of Colorado, Denver, Rhode Island Hospital, Stanford University, Vanderbilt University, Washington University School of Medicine

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedJul 25, 2017
Enrollment StartDec 7, 2017
Primary CompletionJul 22, 2022
TodayJul 2, 2026
Enrollment to primary: 4.6 yearsPosted 8.9 years ago

Interventions

Anastrozoledrug

Anastrozole is an aromatase inhibitor indicated for: * adjuvant treatment of postmenopausal women with hormone receptor-positive breast cancer * first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer * treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Placebo Oral Tabletdrug

matching placebo tablet