CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 57 enrolled
Drug / intervention
N-Acetylcysteine +1 moredrug
Likely dose
N-Acetylcysteine 600mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03238300
NCT03238300Phase 2Completed
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Neuroscience-Informed Treatment Development for Adolescent Alcohol Use

Medical University of South Carolina·interventional·Posted Aug 3, 2017·Updated Jun 22, 2023

In Brief

A Phase 2 clinical trial evaluating N-Acetylcysteine and Placebo Oral Capsule for Alcohol Drinking and Control. Completed, enrolled 57 participants across 1 site.

Detailed Summary

This study will examine the effect of N-Acetylcysteine (NAC), an over-the-counter antioxidant supplement, on brains of youth (ages 15-19) using magnetic resonance imaging (MRI).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAlcohol Drinking, Control
CountriesUnited States
CollaboratorsNational Institute on Alcohol Abuse and Alcoholism (NIAAA)

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedAug 3, 2017
Enrollment StartOct 16, 2017
Primary CompletionMar 1, 2022
TodayJul 2, 2026
Enrollment to primary: 4.4 yearsPosted 8.9 years ago

Interventions

N-Acetylcysteinedrug

N-Acetylcysteine; 600mg capsules by mouth, two pills twice daily (total 2400 mg/day). Participants will undergo MRI (including magnetic resonance imaging and functional MRI during an alcohol cue reactivity task) at baseline, after 10 days of N-Acetylcysteine and after 10 days of placebo.

Placebo Oral Capsuledrug

N-acetylcysteine-matched placebo tablet two pills twice daily. Participants will undergo MRI (including magnetic resonance imaging and functional MRI during an alcohol cue reactivity task) at baseline, after 10 days of N-Acetylcysteine and after 10 days of placebo.