At a glance
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Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect Mechanisms
In Brief
A Phase 1 clinical trial evaluating Endotoxin and Placebo for Depression in Old Age. Completed, enrolled 160 participants across 1 site.
Detailed Summary
Late-life depression is a significant public health concern, and effective interventions for prevention and treatment are needed. Insomnia and inflammation are modifiable targets for depression prevention, and this study is significant in using an experimental approach (i.e., inflammatory challenge) to probe acute inflammatory- and depression responses as a function of insomnia, which will inform identification of molecular targets for pharmacologic interventions, and improvement of insomnia treatments to prevent depression in older adults. Project
Study Details
Timeline
Interventions
Endotoxin
Placebo