CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 714 enrolled
Drug / intervention
Stiolto Respimat +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03265145
NCT03265145Phase 4Completed

Randomized Pragmatic Clinical Trial in a Community-Based Setting Comparing STIOLTO® RESPIMAT® vs. ICS-LABA Plus LAMA in Patients With COPD

Boehringer Ingelheim·interventional·Posted Aug 29, 2017·Updated Jun 14, 2022

In Brief

A Phase 4 clinical trial evaluating Stiolto Respimat, ICS (Inhaled Corticosteroid) (Triple therapy), and 2 other interventions for Pulmonary Disease, Chronic Obstructive. Completed, enrolled 714 participants across 90 sites.

Detailed Summary

The primary objective of this pragmatic study is to compare the time to first moderate or severe COPD exacerbation in patients, not controlled on their current therapy, randomized to Stiolto Respimat versus triple therapy over 12 months of treatment The secondary objectives of this study include: 1. To compare the annual rate of moderate or severe COPD exacerbations for patients on Stiolto Respimat with patients on triple therapy. 2. To compare the time to first severe COPD exacerbation in both treatment arms. 3. To compare the annual rate of severe COPD exacerbations in both treatment arms. 4. To compare the proportion of patients with moderate or severe COPD exacerbations in both treatment arms.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
CollaboratorsCarelon Research

Timeline

Phase 4CompletedFinished
201820192020202120222023202420252026
First PostedAug 29, 2017
Enrollment StartSep 20, 2017
Primary CompletionSep 30, 2020
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 8.8 years ago

Interventions

Stiolto Respimatdrug

Duration - 12 months

ICS (Inhaled Corticosteroid) (Triple therapy)drug

Duration - 12 months

LABA (Long-Acting Beta Agonist) (Triple therapy)drug

Duration - 12 months

LAMA (Long-Acting Muscarinic Antagonist) (Triple therapy)drug

Duration - 12 months