At a glance
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Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers
In Brief
A Phase 1 clinical trial evaluating Lacosamide and Placebo oral capsule for Alcohol Use Disorder. Completed, enrolled 66 participants across 1 site.
Detailed Summary
This is a double-blind, randomized, placebo-controlled, crossover design trial tested the effect of lacosamide on alcohol self-administration and craving following a priming dose of alcohol. The specific objective of this study was to determine whether lacosamide, a novel anticonvulsant that is FDA-approved for treating partial seizures, has effects on alcohol craving and consumption.
Study Details
Timeline
Interventions
Lacosamide titration was done to a target dose of 300mg. Participants took 100 mg of lacosamide once on day 1, 100 mg twice per day from day 2 through day 6 (200 mg daily total), on day 7 the lacosamide dose was increased to 150 mg twice daily (300 mg daily total), and on day 8 the participant took one dose of 150 mg.
Participants took a placebo oral capsule once on day 1, twice per day from day 2 to day 7, and once on day 8.