CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 302 enrolled
Drug / intervention
isatuximab SAR650984 +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03275285
NCT03275285Phase 3Completed

Randomized, Open Label, Multicenter Study Assessing The Clinical Benefit Of Isatuximab Combined With Carfilzomib (Kyprolis®) And Dexamethasone Versus Carfilzomib With Dexamethasone In Patients With Relapse And/Or Refractory Multiple Myeloma Previously Treated With 1 to 3 Prior Lines

Sanofi·interventional·Posted Sep 7, 2017·Updated Feb 9, 2026

In Brief

A Phase 3 clinical trial evaluating isatuximab SAR650984, carfilzomib, and 1 other intervention for Plasma Cell Myeloma. Completed, enrolled 302 participants across 70 sites in 16 countries.

Detailed Summary

The purpose of this study it to compare the efficacity of isatuximab when combined to carfilzomib and dexamethasone versus carfilzomib and dexamethasone in patients with multiple myeloma already treated with 1 to 3 prior lines of therapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Brazil, Canada, Czechia, France, Greece, Hungary, Italy, Japan, New Zealand, Russia, South Korea, Spain, Turkey (Türkiye), United Kingdom, United States
Collaborators--

Timeline

Phase 3CompletedFinished
201820192020202120222023202420252026
First PostedSep 7, 2017
Enrollment StartOct 25, 2017
Primary CompletionJan 14, 2022
Study CompletionJan 3, 2025
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 8.8 years ago

Interventions

isatuximab SAR650984drug

Pharmaceutical form: solution for infusion Route of administration: intravenous

carfilzomibdrug

Pharmaceutical form: solution for infusion Route of administration: intravenous

dexamethasonedrug

Pharmaceutical form: tablets or solution for infusion Route of administration: oral or intravenous