CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 7 enrolled
Drug / intervention
Imiquimod +5 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03276832
NCT03276832Early Ph 1Completed
CompareCT.gov

Pilot Study to Test the Safety and Efficacy of the Combination of Imiquimod and Pembrolizumab for the Treatment of Metastatic Melanoma

Mayo Clinic·interventional·Posted Sep 8, 2017·Updated Mar 19, 2026

In Brief

A Early Phase 1 clinical trial evaluating Imiquimod, Biopsy, and 4 other interventions for Metastatic Melanoma and 3 related conditions. Completed, enrolled 7 participants across 1 site.

Detailed Summary

This pilot early phase I trial studies the side effects and how well imiquimod and pembrolizumab work in treating patients with stage IIIB-IV melanoma. Imiquimod may stimulate the immune system. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving imiquimod and pembrolizumab may work better at treating melanoma.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMetastatic Melanoma, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7
CountriesUnited States
Collaborators--

Timeline

Early Ph 1CompletedFinished
201820192020202120222023202420252026
First PostedSep 8, 2017
Enrollment StartDec 20, 2017
Primary CompletionOct 15, 2019
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 8.8 years ago

Interventions

Imiquimoddrug

Applied cutaneously

Biopsyprocedure

Undergo biopsy

Pembrolizumabbiological

Given IV

Computed Tomographyprocedure

Undergo CT or PET/CT

Positron Emission Tomographyprocedure

Undergo PET/CT

Magnetic Resonance Imagingprocedure

Undergo MRI