CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 26 enrolled / 26 target
Drug / intervention
Pembrolizumabdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03279692
NCT03279692Phase 2ActiveUpdate Overdue (0.3/mo)Completion was 57mo ago

Phase II Trial of Pembrolizumab in Recurrent or Residual High Grade Meningioma

Massachusetts General Hospital·interventional·Posted Sep 12, 2017·Updated Jun 18, 2026

In Brief

A Phase 2 clinical trial evaluating Pembrolizumab for High Grade Meningioma. Active but no longer recruiting, targeting 26 participants across 2 sites.

Signals

Enrollment appears stalled

Detailed Summary

This research study is studying a drug as a possible treatment for High Grade Meningioma. The drug involved in this study is an immunotherapy drug called pembrolizumab

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2Active
2018201920202021202220232024202520262027
First PostedSep 12, 2017
Enrollment StartNov 7, 2017
Primary CompletionSep 18, 2021
Study CompletionDec 31, 2026
TodayJul 2, 2026
Enrollment to primary: 3.9 yearsPosted 8.8 years ago

Arms & Interventions

Pembrolizumabexperimental

* Pembrolizumab will be administered every 3 weeks * Pembrolizumab will be administered through IV infusion

Drug: Pembrolizumab

Interventions

Pembrolizumabdrug

pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells