CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 223 enrolled
Drug / intervention
Perindopril +3 moredrug
Likely dose
Perindopril 4 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03295734
NCT03295734Phase 2Completed
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ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension

University of Alabama at Birmingham·interventional·Posted Sep 28, 2017·Updated Jul 22, 2025

In Brief

A Phase 2 clinical trial evaluating Aerobic exercise, Perindopril, and 2 other interventions for Hypertension and 2 related conditions. Completed, enrolled 223 participants across 2 sites.

Detailed Summary

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension when combined with physical exercise.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension, Aging, Sedentary Lifestyle
CountriesUnited States
CollaboratorsUniversity of Colorado, Denver, AdventHealth Translational Research Institute

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedSep 28, 2017
Enrollment StartMay 29, 2018
Primary CompletionSep 19, 2024
TodayJul 2, 2026
Enrollment to primary: 6.3 yearsPosted 8.8 years ago

Interventions

Aerobic exercisebehavioral

Twice weekly centered based aerobic exercise + 3/week home-based walking

Perindoprildrug

4 mg qd titrated to 8 mg qd perindopril

Losartandrug

50 mg qd titrated to 100 qd losartan

HCTZdrug

12.5 mg qd titrated to 25 qd HCTZ