CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 15 enrolled
Drug / intervention
Amniotic Fluid Eye Drops (AFED) +1 morebiological
Likely dose
Amniotic Fluid Eye Drops (AFED) 0.25 mLfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03298815
NCT03298815Phase 2Completed

A Randomized, Double-Blinded, Placebo-Controlled Study for the Treatment of Ocular Chronic Graft-Versus-Host Disease (GVHD) With Amniotic Fluid Eye Drops (AFED)

University of Utah·interventional·Posted Oct 2, 2017·Updated Apr 9, 2025

In Brief

A Phase 2 clinical trial evaluating Amniotic Fluid Eye Drops (AFED) and Saline Solution for Ocular Graft Versus Host Disease. Completed, enrolled 15 participants across 1 site.

Detailed Summary

A Randomized, Double-blinded, Placebo-Controlled Study for the Treatment of Ocular Chronic Graft Verses Host Disease with Processed Amniotic Fluid (pAF) Drops.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedOct 2, 2017
Enrollment StartDec 20, 2019
Primary CompletionDec 16, 2022
Study CompletionFeb 24, 2023
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 8.8 years ago

Interventions

Amniotic Fluid Eye Drops (AFED)biological

One drop (0.25 mL) in one eye twice daily for up to 3 months

Saline Solutionother

One drop (0.25 mL) in the other eye twice daily for up to 3 months