CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 251 enrolled
Drug / intervention
Agili-C implant +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03299959
NCT03299959N/ACompleted
CompareCT.gov

A Prospective Multicenter Open-label Randomized Controlled Trial of Agili-C™ vs. Surgical Standard of Care (SSOC) for the Treatment of Joint Surface Lesions of the Knee

Smith & Nephew, Inc.·interventional·Posted Oct 3, 2017·Updated Dec 5, 2025

In Brief

A clinical study evaluating Agili-C implant and SSOC for Cartilage or Osteochondral Defects in the Knee and Up to Moderate Osteoarthritis. Completed, enrolled 251 participants across 26 sites in 8 countries.

Detailed Summary

The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee. The patient population is heterogeneous, involving different kinds of joint surface lesions: focal cartilage lesions, osteochondral defects and mild to moderate osteoarthritis, including multiple defects.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
CountriesBelgium, Hungary, Israel, Italy, Poland, Romania, Serbia, United States
Collaborators--

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedOct 3, 2017
Enrollment StartSep 25, 2017
Primary CompletionNov 14, 2024
TodayJul 2, 2026
Enrollment to primary: 7.1 yearsPosted 8.7 years ago

Interventions

Agili-C implantdevice

Agili-C implant

SSOCprocedure

microfracture and/or debridement