CI

At a glance

ClinicalIndex Comparison Record
Phase 1Active· 50 enrolled / 50 target
Drug / intervention
MUC1 Peptide-Poly-ICLC Vaccine +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03300817
NCT03300817Phase 1ActiveUpdate Overdue (0.5/mo)Completion was 57mo ago

A Pilot Study of MUC1 Vaccine in Current and Former Smokers at High Risk for Lung Cancer

National Cancer Institute (NCI)·interventional·Posted Oct 4, 2017·Updated Jun 12, 2026

In Brief

A Phase 1 clinical trial evaluating Laboratory Biomarker Analysis and MUC1 Peptide-Poly-ICLC Vaccine for Lung Carcinoma. Active but no longer recruiting, targeting 50 participants across 2 sites.

Signals

Enrollment appears stalled

Detailed Summary

This pilot phase I trial studies the side effects and how well MUC1 peptide-Poly-ICLC vaccine works in preventing lung cancer in current and former smokers at high risk for lung cancer. Vaccines made from peptides may help the body build an effective immune response to kill cells. MUC1 peptide-Poly-ICLC vaccine may stimulate the body's immune system and slow or stop the changes from normal to pre-cancer to cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLung Carcinoma
CountriesUnited States
Collaborators--

Timeline

Phase 1Active
2018201920202021202220232024202520262027
First PostedOct 4, 2017
Enrollment StartDec 27, 2017
Primary CompletionSep 23, 2021
Study CompletionDec 1, 2026
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 8.7 years ago

Arms & Interventions

Prevention (MUC1 peptide-Poly-ICLC vaccine)experimental

Patients receive MUC1 peptide-Poly-ICLC vaccine SC at weeks 0, 2, and 10.

Other: Laboratory Biomarker AnalysisBiological: MUC1 Peptide-Poly-ICLC Vaccine

Interventions

Laboratory Biomarker Analysisother

Correlative studies

MUC1 Peptide-Poly-ICLC Vaccinebiological

Given SC