At a glance
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The Effect of Blood Pressure on Cerebral Blood Flow During Propofol Anesthesia
In Brief
A clinical study evaluating MAP set at 80-85 mmHg for 5 min, MAP set at 70-75 mmHg for 5 min, and 1 other intervention for Gastrointestinal Neoplasms and Anesthesia, General. Completed, enrolled 30 participants across 1 site.
Detailed Summary
General anesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered to maintain blood pressure but it is unclear at what level blood pressure should be aimed at during anesthesia. Thirty patients undergoing major abdominal surgery will be included. The study will start one hour after the start of surgery and lasts for approximately half an hour. The purpose of the study is to evaluate whether blood flow to the brain can be increased by maintaining blood pressure at a higher level than that used in clinical practice. In the study, MAP is adjusted to a high, moderate, and low level for a short time. The low level of blood pressure used in the study, corresponds to the level aimed at in clinical practice. The drug noradrenaline will be used to control blood pressure. Blood flow to the brain will be evaluated on the neck using ultrasound.
Study Details
Timeline
Interventions
MAP is set at 80-85 mmHg for 5 min by infusion of noradrenaline.
MAP is set at 70-75 mmHg for 5 min by infusion of noradrenaline.
MAP is set at 60-65 mmHg for 5 min by infusion of noradrenaline.