CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 146 enrolled
Drug / intervention
Aerobic & Cognitive Training (ACT) +3 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03313895
NCT03313895N/ACompleted
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Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training (ACT) in MCI

Arizona State University·interventional·Posted Oct 18, 2017·Updated Apr 25, 2025

In Brief

A clinical study evaluating Aerobic & Cognitive Training (ACT), Cycling Only, and 2 other interventions for Mild Cognitive Impairment. Completed, enrolled 146 participants across 4 sites.

Detailed Summary

This multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease \[AD\] signature cortical thickness, and default mode network \[DMN\]) in older adults with amnestic MCI (aMCI).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMild Cognitive Impairment
CountriesUnited States
CollaboratorsUniversity of Rochester, Mayo Clinic, University of St Thomas, University of Minnesota

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedOct 18, 2017
Enrollment StartJul 5, 2018
Primary CompletionJul 17, 2024
TodayJul 2, 2026
Enrollment to primary: 6.0 yearsPosted 8.7 years ago

Interventions

Aerobic & Cognitive Training (ACT)behavioral

ACT stands for combined aerobic exercise and cognitive training.

Cycling Onlybehavioral

Cycling on a recumbent stationary cycle

Cognitive Training Onlybehavioral

Engage in cognitive training on a computer

Stretching and Mental Stimulating Activitiesbehavioral

Stretching exercises and mental stimulating activities on a computer