CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 10 enrolled
Drug / intervention
NaCl predilution +8 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03314363
NCT03314363N/ACompleted
CompareCT.gov

MEtabolic Consequences of Continuous Renal Replacement Therapy and Impact on Indirect cAlorimetry Study

Universitair Ziekenhuis Brussel·interventional·Posted Oct 19, 2017·Updated May 18, 2022

In Brief

A clinical study evaluating blood gas analysis under citrate predilution, filter replacement, and 7 other interventions for Continuous Renal Replacement Therapy and 3 related conditions. Completed, enrolled 10 participants across 1 site.

Detailed Summary

The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in CRRT and suggest a model to overcome these issues.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsContinuous Renal Replacement Therapy, CO2 Removal, Nutrition Poor, Acute Renal Failure
CountriesBelgium
Collaborators--

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedOct 19, 2017
Enrollment StartApr 26, 2017
Primary CompletionMar 15, 2019
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 8.7 years ago

Interventions

blood gas analysis under citrate predilutionother

blood gas analysis of blood on different sample points and dialysis fluid

filter replacementdevice

Using local protocol: stop and disconnect CRRT, replace filter and reconnect and restart CRRT.

ICdevice

monitor patients during the whole study period with indirect calorimetry

NaCl predilutiondrug

Replace citrate predilution with NaCl

blood gas analysis under NaCl predilutionother

repeat blood gas analysis of blood on different sample points and dialysis fluid

double ultrafiltrationdrug

double the ultrafiltration fluid by augmenting post dilution fluid and keeping ultrafiltration at the same rate.

blood gas analysis under citrate predilution and double ultrafiltration rateother

repeat blood gas analysis of blood on different sample points and dialysis fluid

pause and restart nutritional therapydietary

pause parenteral and enteral nutrition before indirect calorimetry is performed. and restart after first blood analysis for vitamine status

evolution of vitamin and trace elementsother

blood analysis for vitamin and trace elements. Perform this blood analysis after restart of CRRT but before restart of nutritional therapy, 30 minutes after restart of nutritional therapy and 24h after restart of nutritional therapy.