CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 179 enrolled
Drug / intervention
Transcranial Magnetic Stimulation +2 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03314584
NCT03314584N/ACompleted
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Long Term Efficacy of rTMS in Managing MTBI-related Headache

VA Office of Research and Development·interventional·Posted Oct 19, 2017·Updated Aug 7, 2025

In Brief

A clinical study evaluating Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation, and 1 other intervention for Traumatic Brain Injury (TBI). Completed, enrolled 179 participants across 1 site.

Detailed Summary

Persistent headache is one of the most common debilitating symptoms in military personnel suffering from mild traumatic brain injury (MTBI). This study aims to assess the long-term effect of repetitive transcranial magnetic stimulation (rTMS) in managing MTBI related headaches for up to 2-3 months by comparing the treatment effect of active-rTMS to sham-rTMS.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTraumatic Brain Injury (TBI)
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedOct 19, 2017
Enrollment StartJan 1, 2018
Primary CompletionSep 30, 2023
Study CompletionJan 31, 2024
TodayJul 2, 2026
Enrollment to primary: 5.7 yearsPosted 8.7 years ago

Interventions

Transcranial Magnetic Stimulationdevice

Active-repetitive transcranial magnetic stimulation (rTMS) at the left motor cortex.

Sham Transcranial Magnetic Stimulationdevice

Sham rTMS will consist of the same parameters as active, however, the subject will not receive the actual magnetic stimulation to the left motor cortex due to the use of a double sided Active/Sham coil used specifically for research studies.

Magnetic resonance imaging (MRI)other

Brain imaging will be done via MRI prior to the first rTMS/Sham TMS session. Imaging will allow investigators to target specific areas in the brain.