At a glance
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The Dual Role of Intramyocellular Lipids in Mediating Insulin Resistance: Assessing the Mechanisms of the Athlete's Paradox
In Brief
A clinical study evaluating Acute bout of endurance exercise for Insulin Resistance, Diabetes and Lipid Metabolism Disorders. Completed, enrolled 100 participants across 2 sites in 2 countries.
Detailed Summary
Accumulation of intramyocellular lipids (IMCLs) due to increased supply of fatty acids can induce defects in the insulin signaling cascade, causing skeletal muscle insulin resistance. However, the causes for muscle insulin resistance are not well understood. The association of elevated IMCLs and insulin resistance has been shown in obese humans and individuals with type 2 diabetes as well as several animal models of insulin resistance. Despite the strong relationship between IMCLs and insulin resistance, this suggested relationship disappears when well-trained endurance athletes are included into this consideration as this group is highly insulin sensitive. This metabolic enigma has been termed the 'athlete's paradox'. The aim of this project is to resolve the mechanisms contributing to the athlete's paradox.
Study Details
Timeline
Interventions
Individuals will undergo an acute bout of endurance exercise for 90 min at 75% of maximal oxygen uptake.