CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 46 enrolled
Drug / intervention
mechanical ventilationother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03317431
NCT03317431N/ACompleted
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the Mechanism of the Downregulation of Dopamine Receptor in Mechanical Ventilation Induced Lung Injury

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine·observational·Posted Oct 23, 2017·Updated Oct 22, 2018

In Brief

An observational study evaluating mechanical ventilation for Acute Lung Injury. Completed, enrolled 46 participants across 1 site.

Detailed Summary

Dopamine(DA) is a common neurotransmitter that has been known to regulate behavior, movement, cardiovascular，endocrine and gastrointestinal functions, but also functions as an important molecule engaging in the immune systems to possess anti-inflammatory effects. However, its role in ventilator-induced lung injury (VILI) is still unclear. Herein, this study aimed to investigate the therapeutic efficacy of dopamine on ventilation-induced lung endothelial barrier dysfunction and explore the possible underlying molecular mechanisms.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Lung Injury
CountriesChina
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedOct 23, 2017
Enrollment StartMar 20, 2017
Primary CompletionOct 22, 2017
Study CompletionDec 1, 2017
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 8.7 years ago

Interventions

mechanical ventilationother

mechanical ventilation protocol: tidal volume 6-8 ml/kg, positive end-expiratory pressure 5 cmH2O, oxygen concentration 40%; respiratory rate 10-15/min, inspiratory/expiratory ratio 1:1.5.