CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 35 enrolled
Drug / intervention
Drug Level Monitoringother
Likely dose
Not stated in record
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Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03335137
NCT03335137N/ACompleted
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Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients

University Hospital Schleswig-Holstein·observational·Posted Nov 7, 2017·Updated Nov 7, 2017

In Brief

An observational study evaluating Drug Level Monitoring for Antibiotics and 2 related conditions. Completed, enrolled 35 participants across 1 site.

Detailed Summary

At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required. Especially, severe burned patient developing a capillary leak might show lower drug levels than patients without a capillary leak. To compare drug levels of beta-lactam antibiotics, it is the aim of this study to measure pharmacokinetics of Piperacillin/Tazobactam in ICU patients with and without severe burns.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsAntibiotics, Severe Burn, Intensive Care
CountriesGermany
CollaboratorsMedical Clinic III, Dezernat Apotheke

Timeline

N/ACompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedNov 7, 2017
Enrollment StartMay 1, 2014
Primary CompletionMay 31, 2016
Study CompletionDec 31, 2016
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 8.7 years ago

Interventions

Drug Level Monitoringother

Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission