CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 129 enrolled
Drug / intervention
DCC-2618 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03353753
NCT03353753Phase 3Completed

A Phase 3, INterVentional, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of DCC-2618 In Patients With AdvanCed Gastrointestinal Stromal TUmorS Who Have Received Treatment With Prior Anticancer Therapies

Deciphera Pharmaceuticals, LLC·interventional·Posted Nov 27, 2017·Updated Nov 21, 2022

In Brief

A Phase 3 clinical trial evaluating DCC-2618 and Placebo Oral Tablet for Gastrointestinal Stromal Tumors. Completed, enrolled 129 participants across 35 sites in 13 countries.

Detailed Summary

This is a 2-arm, randomized, placebo-controlled, double-blind, international, multicenter study comparing the efficacy of ripretinib (DCC-2618) to placebo in patients who have received treatment with prior anticancer therapies. Prior anticancer therapies must include imatinib, sunitinib, and regorafenib (3 prior therapies). Approximately 120 patients were randomized in a 2:1 ratio to ripretinib 150 mg QD or placebo

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Belgium, Canada, Finland, France, Germany, Italy, Netherlands, Poland, Singapore, Spain, United Kingdom, United States
Collaborators--

Timeline

Phase 3CompletedFinished
201820192020202120222023202420252026
First PostedNov 27, 2017
Enrollment StartFeb 27, 2018
Primary CompletionMay 31, 2019
Study CompletionMay 11, 2022
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 8.6 years ago

Interventions

DCC-2618drug

Oral KIT/PDGFRA kinase inhibitor

Placebo Oral Tabletdrug

Placebo