At a glance
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Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation
In Brief
A clinical study evaluating Transcutaneous vagal nerve stimulation and Sham stimulation for Mild Cognitive Impairment. Completed, enrolled 59 participants across 3 sites.
Detailed Summary
Patients with amnestic mild cognitive impairment (MCI) often have compromised quality of life (QOL). Cognitive impairment is a major contributor to decrements in QOL and progression of MCI often leads to loss of independence and withdrawal from social participation. MCI, in many patients, is an early expression of neurodegenerative disease. Patients with MCI frequently convert to Alzheimer's disease (AD) (12-16 percent by some estimates per year). Treatments for MCI are of limited scope and availability and of limited effectiveness. Thus, there is great need for treatments that can improve cognition and extend QOL in patients with MCI. The investigators propose to investigate the effect of a non-invasive and safe intervention that should have direct influence on brain systems underlying AD, transcutaneous vagal nerve stimulation (tVNS).
Study Details
Timeline
Interventions
Non-invasive stimulation provided by transcutaneous electrical nerve stimulation device at 20Hz, 100 μs pulse width
Sham stimulation will be performed using electrodes placed on earlobe