CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 18 enrolled
Drug / intervention
Not specified
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03373045
NCT03373045N/ACompleted

The CHRONICLE Study: A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals With Severe Asthma in the United States

AstraZeneca·observational·Posted Dec 14, 2017·Updated Sep 24, 2025

In Brief

An observational study for Asthma. Completed, enrolled 18 participants across 175 sites in 2 countries.

Detailed Summary

The CHRONICLE Study is a multi-center, non-interventional, prospective cohort study of adults with severe asthma who do not achieve control with high-dose inhaled corticosteroid (ICS) therapy with additional controllers and/or require systemic corticosteroid or monoclonal antibody therapy. Data will be collected from the healthcare provider in a uniform manner for every patient enrolled using an electronic case report form (eCRF). Data will be collected monthly from patients via web-based surveys. Patients will be followed until study discontinuation or the patient withdraws from the study or death, whichever occurs first. The expectation is that patients will be followed for a period of at least 3 years.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsAsthma
CountriesPuerto Rico, United States
CollaboratorsParexel, MedImmune LLC

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedDec 14, 2017
Enrollment StartFeb 27, 2018
Primary CompletionFeb 14, 2025
TodayJul 2, 2026
Enrollment to primary: 7.0 yearsPosted 8.5 years ago