CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 37 enrolled
Drug / intervention
Botulinum toxin type Adrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03381261
NCT03381261Phase 4Completed

Novel Concepts for OnabotulinumtoxinA (Botox) Mechanisms of Action: Role in Altering the Molecular Environment in Which Pain Fibers Exist

Massachusetts General Hospital·interventional·Posted Dec 21, 2017·Updated Mar 24, 2025

In Brief

A Phase 4 clinical trial evaluating Botulinum toxin type A for Migraine. Completed, enrolled 37 participants across 1 site.

Detailed Summary

To compare Botox-treated and Botox-untreated symptomatic tissues (defined as areas where the head hurts and the pain is felt) of chronic migraine (CM) patients using molecular studies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMigraine
CountriesUnited States

Timeline

Phase 4CompletedFinished
201820192020202120222023202420252026
First PostedDec 21, 2017
Enrollment StartDec 1, 2017
Primary CompletionAug 1, 2023
Study CompletionDec 1, 2023
TodayJul 2, 2026
Enrollment to primary: 5.7 yearsPosted 8.5 years ago

Interventions

Botulinum toxin type Adrug

Injection of Botulinum toxin type A in back of head