At a glance
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Circadian Mechanisms of Cardiovascular Risk in Obesity
In Brief
An observational study evaluating Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle for Cardiovascular Risk Factor and 2 related conditions. Active but no longer recruiting, targeting 17 participants across 1 site.
Detailed Summary
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity. Specifically, in a valid circadian protocol, the investigators aim to study resting cardiovascular risk markers and the reactivity of circadian rhythms in these risk markers to standardized stressors. It is intended to compare results in lean and obese individuals to determine if there are specific risks across the circadian cycle specific to obesity. Furthermore, using an exploratory approach, the investigators propose to explore impairment in pre/post synaptic function in the cardiac left ventricle.
Study Details
Timeline
Interventions
Drugs are used for as part of physiological monitoring and not as interventions, including imaging using radiopharmaceuticals (11C-meta-hydroxyephedrine, and 11C-CGP12177).