CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 111 enrolled
Drug / intervention
Paclitaxel +2 moredrug
Likely dose
300mg DKN-01from record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03395080
NCT03395080Phase 2Completed

A Phase 2 Study Evaluating the Efficacy and Safety of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial, Epithelial Ovarian Cancer, or Carcinosarcoma

Leap Therapeutics, Inc.·interventional·Posted Jan 10, 2018·Updated Aug 1, 2025

In Brief

A Phase 2 clinical trial evaluating Paclitaxel, 300mg DKN-01, and 1 other intervention for Endometrial Cancer and 3 related conditions. Completed, enrolled 111 participants across 17 sites.

Detailed Summary

A Phase 2 Study Evaluating the Efficacy and Safety of DKN-01 as a Monotherapy or in Combination with Paclitaxel in Patients With Recurrent Epithelial Endometrial Cancer, Epithelial Ovarian Cancer, or Carcinosarcoma

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedJan 10, 2018
Enrollment StartMar 5, 2018
Primary CompletionSep 9, 2020
Study CompletionJan 27, 2021
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 8.5 years ago

Interventions

Paclitaxeldrug

Administered by IV infusion

300mg DKN-01drug

Administered by IV infusion

600mg DKN-01drug

Administered by IV infusion