At a glance

ClinicalIndex Comparison Record

Phase 4Completed· 47 enrolled

Drug / intervention

Metformindrug

Likely dose

Metformin 500 mgfrom record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03398356

NCT03398356Phase 4Completed

Compare CT.gov

The Assessment of the Effect of Metformin and Its Serum Concentration on the Concentration of Substances Associated With the Production of Nitric Oxide in Patients With Impaired Carbohydrate Metabolism

Wroclaw Medical University·interventional·Posted Jan 12, 2018·Updated May 27, 2022

In Brief

A Phase 4 clinical trial evaluating Metformin for PreDiabetes and 2 related conditions. Completed, enrolled 47 participants across 1 site.

Detailed Summary

This study evaluates the effect of different doses of metformin on the function of endothelium in people with pre-diabetes. One group of the patients will receive metformin in dose: 1500 mg, the second one will receive 3000 mg/day. The parameters from healthy volunteers will be taken only at the study beginning to compare the test results with the parameters from patients with pre-diabetes. This group will be not treated with metformin (no intervention)

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsPreDiabetes, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT)

CountriesPoland

Collaborators--

Timeline

Phase 4CompletedFinished

201820192020202120222023202420252026

Enrollment StartOct 2017

First PostedJan 2018

Primary CompletionDec 2018

Study CompletionApr 2019

TodayJul 2026

First PostedJan 12, 2018

Enrollment StartOct 20, 2017

Primary CompletionDec 30, 2018

Study CompletionApr 30, 2019

TodayJul 2, 2026

Enrollment to primary: 1.2 yearsPosted 8.5 years ago

Interventions

Metformindrug

for group A: 12 weeks metformin treatment in a final dose 3 x 500 mg for group B: 3 weeks metformin treatment in a dose 3 x 500 mg, next: 3 weeks metformin treatment in a final dose 3 x 1000mg, next: 3 weeks metformin treatment in a dose 3 x 500 mg.