At a glance
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Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
In Brief
A Phase 2 clinical trial evaluating Uterine ERA and microbiome testing and Oral antibiotics and vaginal probiotics for Recurrent Pregnancy Loss and Unexplained Infertility. Completed, enrolled 41 participants across 1 site.
Detailed Summary
The purpose of this study is to determine if patients with recurrent pregnancy loss or unexplained infertility have an altered uterine gene expression or uterine microbiome (micro-organism composition) during the window of embryo implantation. Furthermore we would like to assess for women with an abnormal uterine gene expression whether vaginal progesterone medication improves or alters gene expression and for women with an abnormal microbiome whether antibiotic treatment followed by probiotic treatment normalizes the microbiome.
Study Details
Timeline
Interventions
Uterine fluid and endometrial biopsy collection to test uterine endometrial receptivity array and microbiome.
For subjects with abnormal microbiome results, oral antibiotics and vaginal probiotic treatment will be offered followed by a repeat uterine microbiome biopsy.