CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 5 enrolled
Drug / intervention
Transcranial Alternating Current Stimulation (tACS)device
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03412604
NCT03412604N/ACompleted
CompareCT.gov

Effect of Modulating Gamma Oscillations by Transcranial Alternating Current Stimulation on Brain Structure and Function in Humans

Massachusetts General Hospital·interventional·Posted Jan 26, 2018·Updated Aug 22, 2022

In Brief

A clinical study evaluating Transcranial Alternating Current Stimulation (tACS) for Alzheimer Disease. Completed, enrolled 5 participants across 1 site.

Detailed Summary

This study aims to implement an intervention based on multiple, individualized multifocal tACS stimulation sessions based on individual PET and MRI information in patients with amyloid-positive PET with the hope that this leads to microglia activation and decrease in cerebral amyloid and tau depositions in human patients with AD.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAlzheimer Disease
CountriesUnited States
CollaboratorsDefense Advanced Research Projects Agency

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedJan 26, 2018
Enrollment StartAug 2, 2018
Primary CompletionMay 7, 2019
Study CompletionSep 15, 2019
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 8.4 years ago

Interventions

Transcranial Alternating Current Stimulation (tACS)device

tACS will be applied at a frequency of 40Hz and targeting the area of maximal tracer uptake on amyloid PET imaging using an individualized multielectrode design to maximize the induced electrical current to the target region.