At a glance
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A Randomized, Double-blind Study Comparing 3% Chloroprocaine Versus 2 % Lidocaine/ Epinephrine/ Bicarbonate/ Fentanyl for Epidural Anesthesia in Elective Cesarean Delivery
In Brief
A Early Phase 1 clinical trial evaluating 2% Lidocaine and 3% Chloroprocaine for Surgical Anesthesia, Cesarean Section. Completed, enrolled 70 participants across 1 site.
Detailed Summary
Regional anesthesia is commonly used for elective and emergency cesarean delivery. It provides numerous safety advantages when compared to general anesthesia for both the mother and fetus1. Epidurals also have the added benefit of being able to provide pain relief throughout labor and in the event of cesarean delivery, epidural analgesia can be "extended" to provide surgical anesthesia. Numerous studies have been performed to assess the onset times of various local anesthetics when administered through an epidural catheter. Attempts to reduce anesthetic onset time and improve the quality of intraoperative analgesia have been attempted by using different local anesthetic solutions and by the addition of other drugs to the epidural solution (such as epinephrine, fentanyl and sodium bicarbonate).
Study Details
Timeline
Interventions
2% Lidocaine using a combined spinal-epidural (CSE)
3% Chloroprocaine using a combined spinal-epidural (CSE)