At a glance
ClinicalIndex Comparison Record- ✓Histologically confirmed endometrial carcinoma: endometrioid type, serous, clear cell, carcinosarcoma, or other sarcomas
- ✓FIGO stage IA grade 1 with LVSI, or grades 2-3
- ✓FIGO stage IB grades 1-3
- ✓FIGO stage II grades 1-3
- ✕Stages other than those specified (I, II, or IIIA without EBRT)
- ✕Previous pelvic radiotherapy
- ✕Concurrent malignancy requiring non-protocol anti-cancer treatment other than surgery
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Short Course Adjuvant Vaginal Cuff Brachytherapy (VCB) in Early Endometrial Cancer Compared to Standard of Care (SAVE)
In Brief
A Phase 3 clinical trial evaluating Vaginal Cuff Brachytherapy and Short course vaginal cuff brachytherapy for Endometrial Clear Cell Adenocarcinoma and 8 related conditions. Currently recruiting, targeting 188 participants across 5 sites.
Detailed Summary
This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells. After completion of cohort 1 (108 participants), the protocol was expended to add a second cohort of 80 additional participants, and re-opened study recruitment.
Study Details
Timeline
Interventions
Undergo standard of care vaginal cuff brachytherapy
Undergo short course vaginal cuff brachytherapy