CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 133 enrolled
Drug / intervention
Propofol+ Rocuronium+ Fentanyl 2 mcg/kg+ Inhalational Agent, Bupivacaine 0.125% + Fentanyl 5 mcg/ml +2 moredrug
Likely dose
Propofol+ Rocuronium+ Fentanyl 2 mcg/kg+ Inhalational Agent, Bupivacaine 0.125% + Fentanyl 5 mcg/mlfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03434678
NCT03434678Phase 3Completed

Randomized Controlled Trial of Epidural-General Anesthesia Versus General Anesthesia for Open Pancreaticoduodenectomy: Influence on Complications and Overall Two Year Survival

Memorial Sloan Kettering Cancer Center·interventional·Posted Feb 15, 2018·Updated Jul 30, 2025

In Brief

A Phase 3 clinical trial evaluating Propofol+ Rocuronium+ Fentanyl 2 mcg/kg+ Inhalational Agent, Bupivacaine 0.125% + Fentanyl 5 mcg/ml, Propofol+ Rocuronium+ Fentanyl + Inhalational, and 1 other intervention for Pancreatic Cancer. Completed, enrolled 133 participants across 3 sites.

Detailed Summary

The purpose of this study is to see if there is a difference in complications in patients who have an epidural started earlier (during their surgery) and used as part of the anesthetic in addition to using it for post operative pain compared with patients who receive an epidural later in the surgery to be used only for post operative pain.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 3CompletedFinished
201820192020202120222023202420252026
First PostedFeb 15, 2018
Enrollment StartJan 30, 2018
Primary CompletionJul 10, 2024
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 8.4 years ago

Interventions

Propofol+ Rocuronium+ Fentanyl 2 mcg/kg+ Inhalational Agent, Bupivacaine 0.125% + Fentanyl 5 mcg/mldrug

Patient will have their epidural started at the beginning of the surgery and receive fewer opioid drugs. The epidural is continued into the recovery room.

Propofol+ Rocuronium+ Fentanyl + Inhalationaldrug

Patient will have the standard intraoperative management during surgery and have the epidural started just before being taken to the recovery room.

Open Pancreaticoduodenectomyprocedure

Whipple' Procedure