At a glance
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The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy: A Randomized Control Trial
In Brief
A Phase 4 clinical trial evaluating Acetaminophen and Placebo for Pain. Completed, enrolled 27 participants across 1 site.
Detailed Summary
The purpose of the study is to determine the efficacy of IV acetaminophen when administered to neurosurgical patients at the beginning and end of their surgery. If the result is improved pain control with less opioid consumption postoperatively, then those patients may also experience less opioid related side effects such as nausea/vomiting, pruritus, and sedation. While numerous other studies have failed to show a benefit of IV acetaminophen after neurosurgical procedures, we are studying the administration of 1 g in two doses over the course of the operation.
Study Details
Timeline
Interventions
Acetaminophen 1 g intravenous given at the beginning and end of surgery.
Placebo to match acetaminophen given at the beginning and end of surgery.