CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 360 enrolled
Drug / intervention
MIN-117 5.0 mg +2 moredrug
Likely dose
MIN-117 5.0 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03446846
NCT03446846Phase 2Completed

A Randomized, Double-Blind, Parallel-Group, Placebo Controlled Study to Evaluate the Efficacy and Safety of 2 Fixed Doses (5.0 mg or 2.5 mg) of MIN-117 in Adult Patients With Major Depressive Disorder

Minerva Neurosciences·interventional·Posted Feb 27, 2018·Updated Dec 17, 2020

In Brief

A Phase 2 clinical trial evaluating MIN-117 5.0 mg, MIN-117 2.5 mg, and 1 other intervention for Major Depressive Disorder. Completed, enrolled 360 participants across 47 sites in 7 countries.

Detailed Summary

MIN-117C03 is a 6-week, 3-arm, randomized, double-blind, placebo controlled study to investigate the safety and efficacy of MIN-117 in male and female patients with Major Depressive Disorder, aged 18 to 65 years. Approximately 324 patients were to be randomly assigned to 1 of 3 treatment arms, including placebo, 2.5 mg MIN-117, or 5.0 mg MIN-117, in a 2:1:1 ratio.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBulgaria, Finland, Georgia, Moldova, Poland, Ukraine, United States
Collaborators--

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedFeb 27, 2018
Enrollment StartMar 30, 2018
Primary CompletionNov 21, 2019
Study CompletionDec 13, 2019
TodayJul 2, 2026
Enrollment to primary: 1.6 yearsPosted 8.3 years ago

Interventions

MIN-117 5.0 mgdrug

5.0 mg MIN-117 administered as two MIN-117 2.5 mg capsules as a single dose once daily

MIN-117 2.5 mgdrug

2.5 mg MIN-117 administered as one MIN-117 2.5 mg capsule and one Placebo capsule as a single dose once daily

Placebodrug

Placebo administered as two Placebo capsules as a single dose once daily