At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome
In Brief
A Phase 2 clinical trial evaluating Vancomycin and Placebo for End Stage Renal Disease. Completed, enrolled 15 participants across 1 site.
Detailed Summary
The purpose of this study is to determine if multiple doses of vancomycin over the course of 3 months will perturb the intestinal flora (microbiome) and result in reduced serum concentration of the uremic toxin indoxyl sulfate and p-cresyl sulfate. The design of the study will permit investigators to assess the variability of serum uremic retention solute concentrations with and without antibiotic over a three-month period.
Study Details
Timeline
Interventions
Oral vancomycin 250mg capsules
Placebo Pills distributed by Research Pharmacy labeled "placebo."