CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 19 enrolled
Drug / intervention
splanchnic nerve anesthesia with a local anestheticdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03453151
NCT03453151Phase 2Completed
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Splanchnic Nerve Blockade in Chronic Heart Failure. Splanchnic CHF

Duke University·interventional·Posted Mar 5, 2018·Updated Jul 24, 2020

In Brief

A Phase 2 clinical trial evaluating splanchnic nerve anesthesia with a local anesthetic for Heart Failure. Completed, enrolled 19 participants across 1 site.

Detailed Summary

Patients with chronic heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will undergo a regional nerve block of the splanchnic nerves. This study will be a prospective, uncontrolled clinical trial. The study will not be controlled as invasive monitoring of hemodynamics will be performed, allowing clear demonstration of a cause-effect relationship. The goal of the study is to provide proof of concept. Patients will undergo detailed physiological testing.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHeart Failure
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedMar 5, 2018
Enrollment StartMay 1, 2018
Primary CompletionJun 27, 2019
Study CompletionDec 27, 2019
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 8.3 years ago

Interventions

splanchnic nerve anesthesia with a local anestheticdrug

regional nerve block with a local anesthetic (Lidocaine/Bupivacaine)