At a glance
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Impact of Hypoglycaemia in Patients With Diabetes Mellitus Type 2 on Platelet Activation
In Brief
A clinical study evaluating Euglycaemic Clamp and Hyperinsulinaemic/Hypoglycaemic Clamp for Diabetes Mellitus With Hypoglycemia and 3 related conditions. Completed, enrolled 14 participants across 1 site.
Detailed Summary
This experimental study is planned to investigate the impact of hypoglycaemia on platelet activation parameters (PAP) during a hyperinsulinaemic hypoglycaemic clamp study. The hypothesis that hypoglycaemia in patients with Diabetes Mellitus, Type 2 (T2DM) leads to increased platelet activation will be tested.
Study Details
Timeline
Interventions
All 14 subjects will undergo an euglycaemic clamp at Visit 2 with a plasma Glucose target of 5.5 mmol/L +/- 10% (4 timepoints for platelet activity parameter blood sampling)
All 14 subjects will undergo a hypoglycaemic/hyperinsulinaemic clamp at Visit 3 with 4 timepoints for platelet activity Parameter blood sampling 30 minutes after reaching certain plasma glucose plateaus (5.5 mmol/L; 3.5 mmol/L; 2.5 mmol/L; after recovery again at 5.5 mmol/L)