CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 1,561 enrolled
Drug / intervention
Acetaminophen IV/PO +10 moredrug
Likely dose
Acetaminophen IV/PO 1gfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03472469
NCT03472469Phase 4Completed
CompareCT.gov

MAST Trial: Multi-modal Analgesic Strategies in Trauma

The University of Texas Health Science Center, Houston·interventional·Posted Mar 21, 2018·Updated Jun 18, 2021

In Brief

A Phase 4 clinical trial evaluating Acetaminophen IV/PO, Acetaminophen PO, and 9 other interventions for Nonspecific Pain Post Traumatic Injury. Completed, enrolled 1,561 participants across 1 site.

Detailed Summary

This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared \[original multimodal pain regimen (MMPR) compared to multi-modal analgesic strategies for trauma (MAST) MMPR\].

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNonspecific Pain Post Traumatic Injury
CountriesUnited States
CollaboratorsNational Center for Advancing Translational Sciences (NCATS)

Timeline

Phase 4CompletedFinished
201820192020202120222023202420252026
First PostedMar 21, 2018
Enrollment StartApr 2, 2018
Primary CompletionJul 3, 2019
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 8.3 years ago

Interventions

Acetaminophen IV/POdrug

Acetaminophen 1g IV/PO every 6 hours

Acetaminophen POdrug

Acetaminophen 1g PO every 6 hours

Ketorolacdrug

Ketorolac 30mg IV once

Celebrexdrug

Celebrex 200mg PO every 12 hours

Naproxendrug

Naproxen 500mg PO every 12 hours

Tramadoldrug

Tramadol 100mg PO every 6 hours

Pregabalindrug

Pregabalin 100mg PO every 8 hours

Gabapentindrug

Gabapentin 300mg PO every 8 hours

Lidocainedrug

Lidocaine patch every 12 hours

Opioidsdrug

Opioid options include: Oral Opioids (Codeine, Tramadol, Hydrocodone, Oxycodone, Methadone, Morphine, Hydromorphone); Transdermal Opioid (Fentanyl); Intravenous Opioids (Morphine, Hydromorphone, Fentanyl)

Regional anesthesiadrug

Regional anesthesia