CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 14 enrolled
Drug / intervention
Ipilimumab +2 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03472586
NCT03472586Phase 2Completed

Ipilimumab and Nivolumab in Combination With Immunoembolization for the Treatment of Metastatic Uveal Melanoma

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·interventional·Posted Mar 21, 2018·Updated Apr 24, 2025

In Brief

A Phase 2 clinical trial evaluating Ipilimumab, Nivolumab, and 1 other intervention for Metastatic Malignant Neoplasm in the Liver and 2 related conditions. Completed, enrolled 14 participants across 1 site.

Detailed Summary

This phase II trial studies ipilimumab and nivolumab with immunoembolization in treating patients with uveal melanoma that has spread to the liver. Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Immunoembolization may kill tumor cells due to loss of blood supply and develop an immune response against tumor cells. Giving ipilimumab and nivolumab with immunoembolization may work better in treating patients with uveal melanoma.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedMar 21, 2018
Enrollment StartMay 2, 2018
Primary CompletionDec 31, 2022
Study CompletionDec 31, 2024
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 8.3 years ago

Interventions

Ipilimumabbiological

Given IV

Nivolumabbiological

Given IV

Embolization Therapydrug

Undergo immunoembolization