At a glance
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Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease 2
In Brief
An observational study evaluating Diagnostic tests for Angina Pectoris and 3 related conditions. Completed, enrolled 1,732 participants across 5 sites.
Detailed Summary
In a cohort of symptomatic patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To investigate and compare the diagnostic precision of Rubidium Positron Emission Tomography (Rb PET) and 3 Tesla Cardiac Magnetic Resonance imaging (3T CMRI) in patients where CCTA does not exclude significant coronary artery disease (CAD) using invasive coronary angiography with fractional flow reserve (ICA-FFR) as reference standard. 2. To evaluate the diagnostic precision of quantitative flow ratio (QFR) and ICA-FFR in patients where CCTA does not exclude significant CAD using Rb PET and 3T CMRI as reference standard. 3. To show superiority for the CADScor®System compared to the Diamond-Forrester score in detection of CAD with CCTA and ICA quantitative coronary angiography (ICA-QCA) as reference standard. 4. To study the diagnostic accuracy of computed tomography fractional flow reserve (CT-FFR) in patients where CCTA does not exclude significant CAD with ICA-FFR as reference standard. 5. To identify and characterize genetic risk variants´ and circulating biomarkers´ importance in developing CAD. 6. To evaluate the bone mineral density in the hip and spine and correlate this to the degree of vascular calcification.
Study Details
Timeline
Interventions
Head-to-head comparison between: * CADScor and Diamond-Foster score * Rb PET and 3T CMRI * QFR and ICA-FFR