At a glance
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Role of Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclamptic Pregnancy
In Brief
A Early Phase 1 clinical trial evaluating Salsalate Oral Tablet and Placebo Oral Tablet for Preeclampsia. Completed, enrolled 24 participants across 2 sites.
Detailed Summary
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs is unclear but may be related to blood vessel damage and increased inflammation that occurs during the preeclamptic pregnancy and persists postpartum. The purpose of this investigation is to 1) determine the mechanisms contributing to this lasting blood vessel damage and chronic inflammation, and to 2) identify factors (both physiological and pharmacological) that mitigate these negative effects in order to inform better clinical management of cardiovascular disease risk in women who have had preeclampsia.
Study Details
Timeline
Interventions
1500mg twice daily for 4 days prior to experimental testing
Placebo oral table twice daily for 4 days prior to experimental testing