CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 24 enrolled / 24 target
Drug / intervention
Retinoic acid +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03491267
NCT03491267Early Ph 1CompletedUpdate Overdue (0.2/mo)Completion was 19mo ago
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Pilot Exploratory Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis

Johns Hopkins University·interventional·Posted Apr 9, 2018·Updated Jun 12, 2026

In Brief

A Early Phase 1 clinical trial evaluating Retinoic acid, Laser, and 1 other intervention for Central Centrifugal Cicatricial Alopecia (CCCA). Completed, enrolled 24 participants across 1 site.

Signals

Enrollment appears stalled

Detailed Summary

The investigators have extensive evidence in mouse that wounding leads to the generation of new hair follicles in the skin. This can be an important new therapy for patients with scarring, but especially those with alopecia. The question is whether gentle wounding in human subjects can cause the generation of a new hair follicle. The plan is to first carefully map a small area of the scalp without hair follicles. Investigators will then try various modalities of gentle wounding (including fractionated Carbon Dioxide (CO2) laser, mild curetting) of the surface epithelium in the presence and absence of FDA approved topical medications (including retinoids). Investigators will then prospectively monitor the area for hair growth both by noninvasive visual monitoring (including photographs and dermoscopy) and biopsies. The outcomes of this study hopefully will allow new therapies for especially scarring alopecia conditions where hair follicles are completely lost and there are no current therapies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCentral Centrifugal Cicatricial Alopecia (CCCA)
CountriesUnited States
CollaboratorsNational Institute Of Arthritis & Musculoskeletal & Skin Diseases

Timeline

Early Ph 1CompletedFinished
201820192020202120222023202420252026
First PostedApr 9, 2018
Enrollment StartJan 1, 2018
Primary CompletionNov 1, 2024
TodayJul 2, 2026
Enrollment to primary: 6.8 yearsPosted 8.2 years ago

Arms & Interventions

Subjects with alopecia-- area treatedexperimental

One area will be treated

Drug: Retinoic acidDevice: Laser
Subjects with alopecia-- area un-treatedexperimental

One area will be un-treated

Drug: Sham treatmentDevice: Sham treatment

Interventions

Retinoic aciddrug

The study team will treat skin with topical retinoic acid

Laserdevice

The study team treat skin with a surface laser.

Sham treatmentdrug

No drug will be given

Sham treatmentdevice

No laser treatment will be given