CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 680 enrolled
Drug / intervention
Incentives for negative EtG test +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

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NCT03492216N/ACompleted
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Drinkers' Intervention to Prevent Tuberculosis (DIPT Study)

University of California, San Francisco·interventional·Posted Apr 10, 2018·Updated Jan 13, 2025

In Brief

A clinical study evaluating Incentives for negative EtG test and Incentives for positive IsoScreen test for HIV/AIDS and Tuberculosis. Completed, enrolled 680 participants across 2 sites.

Detailed Summary

There is an urgent global need to decrease the high mortality of tuberculosis (TB) in persons with HIV as TB is the leading cause of death among persons with HIV worldwide. The DIPT (Drinkers' Intervention to Prevent TB) study is a randomized, 2x2 factorial trial among HIV/TB co-infected adults in Uganda with heavy alcohol use (n=680 persons, 340 each U01). The goal of the study is to determine whether economic incentive interventions can promote both reduced alcohol use and isoniazid (INH) pill taking among HIV/TB co-infected adult heavy drinkers, during isoniazid preventive therapy (IPT: a six-month course of INH) at HIV clinics in southwestern Uganda. Participants will be randomized to one of four arms: Arm 1: no incentives (control); Arm 2: economic incentives for decreasing alcohol use only; Arm 3: economic incentives for IPT adherence only; Arm 4: economic incentives for decreasing alcohol use and for IPT adherence (rewarded independently).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHIV/AIDS, Tuberculosis
CountriesUganda
CollaboratorsInfectious Diseases Research Collaboration, Uganda, Mbarara University of Science and Technology

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedApr 10, 2018
Enrollment StartApr 16, 2018
Primary CompletionFeb 1, 2022
Study CompletionAug 2, 2022
TodayJul 2, 2026
Enrollment to primary: 3.8 yearsPosted 8.2 years ago

Interventions

Incentives for negative EtG testbehavioral

Economic incentives are given to the study participant contingent on point-of-care (POC) urine ethyl glucuronide (EtG) \<300 ng/mL with the amount of the incentive escalating with each subsequent negative EtG test.

Incentives for positive IsoScreen testbehavioral

Economic incentives contingent on POC (IsoScreen) INH urine positive tests with the amount of the incentive escalating with each subsequent positive IsoScreen test.